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![]() 9) reported that MMPs play an important role in the pulp tissue destruction in inflamed pulp and periapical lesion. There are multiple members of family, including interstitial collagenase (MMP-1), neutrophil collagenage (MMP-8), stromelysin-1 (MMP-3), stromelysin-2 (MMP-10), gelatinase B (MMP-9). They are group of zinc-dependent proteinases, secreted or released by host cells (ie, PMN, macrophage, bone cell, fibroblast) as proenzymes. Matrix metalloproteinases (MMPs) form a family of structurally related but genetically distinct endopeptidases expressed at low level in normal tissue, but upregulated during inflammation 8).
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